Innovative Allergy

From birth throughout life, preventing and treating allergies and immune conditions so you can

Breathe Clearer, Sleep Better, Eat Freely, Enjoy Pets & Live Normal Again!

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Board-certified allergist and immunologist with expertise in allergic and immunologic conditions affecting adults and kids. Voted Consistently Best Houston Top Doctor in Allergy & Immunology since 2013 by Houstonia.

DAT Q. TRAN | MD, FAAAAIAllergist, Immunologist, Scientist, Innovator
An Allergist | I care for kids and adults with allergic diseases to provide them with a more comfortable life. The symptoms of allergy, such as itching, swelling and sneezing, might not always be solely immune mediated, but also neurological, psychological and other factors. Recognizing these intricacies to balance between a medical and homeopathic approach will provide more meaningful treatment while minimizing potential side effects.

An Immunologist | The purpose of the immune system is to provide protection against microbes. Too less or too much of its activities can result in diseases. Non-microbial signaling can trigger aberrant immune responses, causing inflammatory and stress reactions. I help patients suffering with too weak or too strong of an immune system regain a delicate balance and not swing from one end to the other.

A Scientist | To care for patients is to implement existing knowledge and guidelines. To cure patients is to understand their problems and to create new knowledge when there is none. Avoidance is not a treatment for food allergy but a lack of knowledge. It is absolutely unfulfilling to make the diagnosis of food allergy and then recommend avoidance. With this constant frustration, I am developing novel allergen immunotherapy targeting sensory receptors and our microbiome as adjuvants to achieve immunological tolerance. I am also developing regulatory T cell therapy to prevent and treat autoimmune conditions such as graft versus host disease, as well as modulate their functions to optimize anti-tumor cellular immunotherapy.

An Innovator | There are always opportunities to improve when one chooses not to accept something that can be better. The process of physician-patient care is extremely expensive yet highly inefficient, with the patients typically getting the least benefits. Developing an EMR system that focuses on transparency, accessibility and direct communication without redundancy will provide more meaningful patient care.


1. Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2.

Hoang TK, He B, Wang T, Tran DQ, Rhoads JM, Liu Y. American journal of physiology. Gastrointestinal and liver physiology. 2018; 315(2):G231-G240.

2. Adenosine A2A Receptor Deletion Blocks the Beneficial Effects of Lactobacillus reuteri in Regulatory T-Deficient Scurfy Mice.

He B, Hoang TK, Tran DQ, Rhoads JM, Liu Y. Frontiers in immunology. 2017; 8:1680.

3. Lactobacillus reuteri for Infants with Colic: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

Fatheree NY, Liu Y, Taylor CM, Hoang TK, Cai C, Rahbar MH, Hessabi M, Ferris M, McMurtry V, Wong C, Vu T, Dancsak T, Wang T, Gleason W, Bandla V, Navarro F, Tran DQ, Rhoads JM. The Journal of pediatrics. 2017; 191:170-178.e2.

4. Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.

He B, Hoang TK, Wang T, Ferris M, Taylor CM, Tian X, Luo M, Tran DQ, Zhou J, Tatevian N, Luo F, Molina JG, Blackburn MR, Gomez TH, Roos S, Rhoads JM, Liu Y. The Journal of experimental medicine. 2017; 214(1):107-123.

5. CD31 Expression on CD4+ Cells: A Simple Method for Quantitation of Recent Thymus Emigrant CD4 Cells.

Zakhour R, Tran DQ, Heresi GP, Degaffe G, Bell CS, Donnachie E, Zhang W, Pérez N, Benjamins LJ, Del Bianco G, Rodriguez G, Murphy JR. The American journal of tropical medicine and hygiene. 2016; 95(4):970-972.

6. Recent Thymus Emigrant CD4+ T Cells Predict HIV Disease Progression in Patients With Perinatally Acquired HIV.

Zakhour R, Tran DQ, Degaffe G, Bell CS, Donnachie E, Zhang W, Pérez N, Benjamins LJ, Del Bianco G, Rodriguez G, Murphy JR, Heresi GP. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016; 62(8):1029-1035.

7. Hypoallergenic formula with Lactobacillus rhamnosus GG for babies with colic: A pilot study of recruitment, retention, and fecal biomarkers.

Fatheree NY, Liu Y, Ferris M, Van Arsdall M, McMurtry V, Zozaya M, Cai C, Rahbar MH, Hessabi M, Vu T, Wong C, Min J, Tran DQ, Navarro F, Gleason W, Gonzalez S, Rhoads JM. World journal of gastrointestinal pathophysiology. 2016; 7(1):160-70.

8. Circulating L-selectin expressing-T cell subsets correlate with the severity of Foxp3 deficiency autoimmune disease.

Liu Y, Hoang TK, Wang T, He B, Tran DQ, Zhou J, Tatevian N, Rhoads JM. International journal of clinical and experimental pathology. 2016; 9(2):899-909. NIHMSID: NIHMS967678

9. Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.

Degaffe G, Zakhour R, Zhang W, Contreras GA, Bell CS, Rodriguez G, Del Bianco G, Pérez N, Benjamins LJ, Murphy JR, Heresi GP, Tran DQ. Clinical and experimental immunology. 2015; 180(1):108-17.

10. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.

Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G. Science (New York, N.Y.). 2014; 345(6204):1623-1627.

11. Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis.

Liu Y, Tran DQ, Fatheree NY, Marc Rhoads J. American journal of physiology. Gastrointestinal and liver physiology. 2014; 307(2):G177-86.

12. FoxP3⁺ regulatory T cells attenuate experimental necrotizing enterocolitis.

Dingle BM, Liu Y, Fatheree NY, Min J, Rhoads JM, Tran DQ. PloS one. 2013; 8(12):e82963.

13. Peripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and function.

Dhamne C, Chung Y, Alousi AM, Cooper LJ, Tran DQ. Frontiers in immunology. 2013; 4:253.

14. Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.

Uzel G, Sampaio EP, Lawrence MG, Hsu AP, Hackett M, Dorsey MJ, Noel RJ, Verbsky JW, Freeman AF, Janssen E, Bonilla FA, Pechacek J, Chandrasekaran P, Browne SK, Agharahimi A, Gharib AM, Mannurita SC, Yim JJ, Gambineri E, Torgerson T, Tran DQ, Milner JD, Holland SM. The Journal of allergy and clinical immunology. 2013; 131(6):1611-23.

16. In vitro suppression assay for functional assessment of human regulatory T cells.

Tran DQ. Methods in molecular biology (Clifton, N.J.). 2013; 979:199-212.

17. Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.

Fu K, Sun X, Zheng W, Wier EM, Hodgson A, Tran DQ, Richard S, Wan F. Nature communications. 2013; 4:1909.

18. Safety and tolerability of Lactobacillus reuteri DSM 17938 and effects on biomarkers in healthy adults: results from a randomized masked trial.

Mangalat N, Liu Y, Fatheree NY, Ferris MJ, Van Arsdall MR, Chen Z, Rahbar MH, Gleason WA, Norori J, Tran DQ, Rhoads JM. PloS one. 2012; 7(9):e43910.

19. Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.

Kim YC, Bhairavabhotla R, Yoon J, Golding A, Thornton AM, Tran DQ, Shevach EM. Blood. 2012; 119(12):2810-8.

20. TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells.

Tran DQ. Journal of molecular cell biology. 2012; 4(1):29-37.

21. T regulatory cells in cancer: recent advances and therapeutic potential.

Elkord E, Alcantar-Orozco EM, Dovedi SJ, Tran DQ, Hawkins RE, Gilham DE. Expert opinion on biological therapy. 2010; 10(11):1573-86.

22. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM. Journal of immunology (Baltimore, Md. : 1950). 2010; 184(7):3433-41.

23. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(32):13445-50.

26. Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.

Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, Shevach EM. Journal of immunology (Baltimore, Md. : 1950). 2009; 182(5):2929-38.

27. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.

Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O’Shea JJ, Shevach EM. The Journal of experimental medicine. 2008; 205(9):1975-81.

28. The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.

Shevach EM, Tran DQ, Davidson TS, Andersson J. European journal of immunology. 2008; 38(4):915-7.

Arnold SF, Bergeron JM, Tran DQ, Collins BM, Vonier PM, Crews D, Toscano WA Jr, McLachlan JA. Biochemical and biophysical research communications. 1997; 235(2):336-42.

33. Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast.

Jin L, Tran DQ, Ide CF, McLachlan JA, Arnold SF. Biochemical and biophysical research communications. 1997; 233(1):139-46.

34. Inhibition of progesterone receptor activity in yeast by synthetic chemicals.

Tran DQ, Klotz DM, Ladlie BL, Ide CF, McLachlan JA, Arnold SF. Biochemical and biophysical research communications. 1996; 229(2):518-23.

35. The anti-estrogenic activity of selected polynuclear aromatic hydrocarbons in yeast expressing human estrogen receptor.

Tran DQ, Ide CF, McLachlan JA, Arnold SF. Biochemical and biophysical research communications. 1996; 229(1):101-8.

36. The inhibition of estrogen receptor-mediated responses by chloro-S-triazine-derived compounds is dependent on estradiol concentration in yeast.

Tran DQ, Kow KY, McLachlan JA, Arnold SF. Biochemical and biophysical research communications. 1996; 227(1):140-6.

Personalized Healthcare Through Innovation

Cookbook medicine is not security, instead meaningful patient care is our responsibility. As expert in the area of allergy and immunology, we have to be pioneers and go outside the box to deliver the most innovative treatment. Our patients seek us because no one else has offered an answer or solution to their debilitating medical conditions. To be meaningful requires personalized medicine and accessibility, because each patient is unique and their conditions are dynamic. Therefore, optimal care is not just 30-60 minute visit and a 3-6 month follow-up. A continuous dialogue between the patients and our healthcare team is necessary to better understand their disorders and fine tune their treatments to optimize efficacy and minimize side effects. With many of these complex medical illnesses, often times there isn’t a convenient diagnostic testing and a single pill to resolve the issue. It would require multidisciplinary specialty care to bring the patient back to a better health. At Innovative Allergy Clinic, we will be at the forefront to help you navigate through this complicated medical system so that one day you will feel better and live better.

  • Personalized patient care

  • Convenient accessibility

  • Innovative treatment

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Our Values

The art of medicine and patient care is to focus on the patient first and provide the most meaningful care. Use medicines appropriately and effectively to treat a condition and be vigilant of when to discontinue treatment to minimize side effects. In other words, don’t just prescribe medicines but have a treatment plan and expectation. If the expectation is not achieved, then change the treatment plan. Maintain good communication and transparency with the patients and always be accessible. Ultimately, success is seeing my patients and saying hello to them in the parks, grocery stores and community.

At Innovative Allergy Clinic, it is not simply to to offer standard medical diagnosis and treatments. We are always innovating for more curative immunotherapy and efficient patient-focused medical care. Our vision:

  • Treatments for food allergy beyond just avoidance
  • Convenient, effective and painless immunotherapy for environmental allergies
  • Transparent and easily accessible medical care between the patient and physician

If you’re not completely satisfied, then we are not completely satisfied. We stand behind our services and treatments. We are unique and the only medical practice that offers 100% satisfaction guarantee for the first 6 months on our novel oral immunotherapy, OLLEREG. As our patients, you become our families. You can contact us 24/7 via phone, text or email directly to our physician or advanced practice provider.

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patient satisfaction best allergist immunologist houston texas


Kind words can be short and easy to speak, but their echoes are truly endless.

Amazing doctor doesn’t even begin to describe Dr. Tran and his team! We are sooooooo happy to have him leading our Dream Team of doctors! Our girls are doing amazing thanks to finally having the right doctors in place and Dr. Tran is at the center of that!


Dr. Tran is an amazing doctor. He has helped me go from dreading going outdoors to enjoying my time outside. I used to take 3 allergy shots twice a week for years, take 3 or more medications daily and still did not have complete relief from my seasonal allergy symptoms. Since I started on his OLLEREG, I am able to enjoy my time outdoors and only very occasionally take an antihistamine.


Dr. Tran is truly amazing. He views his patients as a whole and treats the whole person instead of one symptom. Dr. Tran listens to his patients and family members and speaks to them in a manner that is comforting and easy to understand. He sees my medically complex 5 year old daughter and recently alerted us to an urgent situation with my daughter that was not caught by her other providers. He saved her life. We travel 7 hours to see Dr. Tran and I would highly recommend him to everyone.




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